Title:
Concepts of tissue-biomaterial interactions : fundamentals and new directions
Author:
Bizios, Rena, author.
ISBN:
9781394300013
9781119841012
9781119841029
Physical Description:
1 online resource
Contents:
Cover -- Title Page -- Copyright -- Contents -- List of Figures -- List of Tables -- Preface -- Acknowledgments -- About the Companion Website -- Chapter 1 Materials for Prosthetic Devices and Implants Through the Ages -- 1.1 Traditional External Prosthetic Devices -- 1.2 Implantable Devices -- 1.3 Materials Used for Implants -- References -- Chapter 2 Lessons Learned from Physiology -- 2.1 Tissue Wound Healing: Introduction -- 2.2 The Process of Normal Wound Healing in Injured Tissues -- 2.2.1 The Importance of Blood Supply in the Human Body -- 2.2.2 Blood Composition -- 2.2.3 Hematopoiesis (Formation of Blood Cells) -- 2.3 Blood Clotting (Thrombosis) -- 2.3.1 Platelet Anatomy -- 2.3.2 Platelet Function -- 2.3.3 Platelet Function in Hemostasis -- 2.3.4 The Plasma Coagulation Cascade -- 2.3.5 "Synergisms" in the Process of Thrombus Formation -- 2.3.6 The Fate of Thrombi -- 2.3.7 Control of Thrombosis -- 2.4 Fibrinolysis -- 2.5 Inflammation -- 2.5.1 Introduction -- 2.5.2 Inflammation in the Tissue Wound Healing Process -- 2.5.3 The Blood Cells of Inflammation -- 2.5.4 Leukocyte Response to Invading Pathogens -- 2.5.5 Neutrophil Response to Invading Pathogens -- 2.5.6 Monocyte/Macrophage Response to Invading Pathogens -- 2.6 The Proliferation/Repair Stage of the Tissue Wound Healing Process -- 2.6.1 Cytokines and Growth Factors -- 2.6.2 Tissue Regeneration -- 2.6.3 The Proliferative Capacity of Human Cells -- 2.6.3.1 An Introduction to Stem Cells -- 2.6.4 Synthesis and Deposition of New Extracellular Matrix Components -- 2.6.5 Formation of New Blood Vessels -- 2.6.6 Restoration of Nerves -- 2.7 Remodeling/Maturation Stage of the Tissue Wound Healing Process -- References -- Chapter 3 Lessons Learned from Pathology -- 3.1 Blood-Coagulation-Related Clinical Complications -- 3.2 Prevention of Blood Clots: A Clinical Perspective.
3.3 Fibrinolysis: Clinical Practice -- 3.4 Inflammation-Related Pathological Outcomes -- 3.5 Proliferation/Repair and Remodeling/Maturation-Related Pathological Outcomes -- 3.5.1 The Skin Wound Healing Process -- 3.5.2 Undesirable Skin Wound Healing Outcomes: Scars -- 3.5.3 Scarless Wound Healing During Early Gestation of the Fetus: A Special Case -- 3.5.4 Parameters Affecting Scarless Wound Healing -- 3.5.5 Closing Remarks -- 3.6 Other Undesirable Tissue Wound Healing Outcomes -- 3.7 Potential Lessons Learned from Malignant Tumor Pathology -- 3.8 Cancer and Implants -- 3.9 The Patient Factor -- References -- Chapter 4 Lessons Learned from Biology -- 4.1 Mammalian Cells -- 4.1.1 Cell Functions -- 4.2 The Extracellular Matrix -- 4.3 Brief Introduction to Proteins -- 4.4 Protein Adsorption on Substrates -- 4.5 Protein Interactions with Substrates: The "Substrate Prospective" -- 4.6 Adsorption of Proteins from Multicomponent Solutions. The Vroman Effect -- 4.7 Protein-Mediated Cell Interactions with Substrates -- 4.8 Protein and Cell Interactions with Materials: Applications -- 4.9 Select Chemical Modification of Substrate Surfaces -- 4.9.1 Directed Mammalian Cell Adhesion on Chemically-Modified, Protein-Containing, Patterned Surfaces -- 4.10 Select Mammalian Cell Adhesion on Chemically-modified, Peptide-Containing, Material Surfaces -- 4.11 Other Mammalian Cell Functions on Chemically-Modified, Peptide-Containing Material Surfaces -- 4.12 Closing Remarks -- 4.13 Protein and Cell Interactions with Nanostructured Materials -- 4.13.1 Challenges Regarding Implantable Nanostructured Materials -- 4.13.2 Closing Remarks -- References -- Chapter 5 Tissue Wound Healing in the Presence of Implants -- 5.1 Introduction -- 5.2 Blood Coagulation and Fibrinolysis in the Presence of Implants -- 5.3 Inflammation in the Presence of Implants.
5.4 Proliferation/Repair and Remodeling/Maturation in the Presence of Implants -- 5.4.1 Chronic Nonhealing Wounds -- 5.4.2 Clinical Complications Regarding Vascular Grafts -- 5.4.3 Closing Remarks -- 5.5 Effects of the Biological/Physiological Milieu on Biomaterials -- 5.6 The Fate of Implants -- References -- Chapter 6 Infection -- 6.1 Introduction -- 6.1.1 Introduction to Biofilms -- 6.1.2 The Process of Biofilm Formation -- 6.2 Clinical Treatments of Infection -- 6.2.1 Medical Treatments of Infection -- 6.2.2 Infections Associated with Implants -- 6.2.3 Implant Material Properties Contributing to Infection -- 6.2.4 Potential Strategies to Overcome Implant-Associated Infections -- 6.2.5 Current Research Endeavors to Overcome Bacterial Infections of Implanted Devices -- 6.3 Future Directions: Challenges and Opportunities -- References -- Chapter 7 Sterile Conditions. Sterilization of Implants -- 7.1 Introduction -- 7.2 Determining Implant-Related Sterile Conditions -- 7.3 Methods for Implant Sterilization -- 7.3.1 Autoclaving or Steam Sterilization -- 7.3.2 Ethylene Oxide (EtO/EO) Sterilization -- 7.3.3 Sterilization Using Emitted Radiation -- 7.3.4 Development of New Sterilization Methods -- 7.4 Biomaterials: The Biomedical Engineering Connection -- 7.4.1 Sterile Conditions and Practices in Surgery Rooms and Hospitals -- References -- Chapter 8 Evaluation of Biocompatibility -- 8.1 Mechanical Properties of Materials -- 8.1.1 Mechanical Tests In Vitro -- 8.1.2 Material Tests In Vitro. Determination of Material Degradation -- 8.2 In Vitro Hemocompatibility (Blood Compatibility) Tests -- 8.2.1 Hemocompatibility-Related Tests -- 8.2.2 Tests Under Static and Dynamic Conditions -- 8.3 Cultured Cell Models -- 8.3.1 Determination of Protein Interactions on Synthetic Materials.
8.3.2 Determination of Cultured Cell Interactions with Proteins Pre-adsorbed on Synthetic Materials -- 8.3.3 Cultured Cell Models: Closing Remarks -- 8.4 Animal Tests -- 8.4.1 Regulations and Laws Regarding Animals in Research -- 8.4.2 Special Considerations Regarding Animals Used in Research -- 8.4.3 Nonfunctional, Ex Vivo, and Functional Tests -- 8.4.4 Closing Remarks -- 8.5 Clinical Trials -- 8.5.1 An Introduction to the Food and Drug Administration (FDA) of the United States (US) -- 8.5.2 Requirements for Clinical Trial Applications -- 8.5.3 Patient Participation in Clinical Trials -- 8.5.4 Phases of Clinical Trials -- 8.5.5 Requirements for Successful Clinical Trials -- 8.5.6 Undesirable Outcomes -- 8.5.7 Closing Remarks -- References -- Chapter 9 Lessons Learned from Implant Failure, Retrieval, and Evaluation -- 9.1 Complications Leading to Implant Failure Post Implantation -- 9.2 Examples of Vascular Implant Failure Post Implantation -- 9.3 Reasons for Failure of Orthopedic and Dental Implants Post Implantation -- 9.4 Examples of Orthopedic and Dental Implant Failure Post Implantation -- 9.5 Etiology of Implant Failure Post Implantation -- 9.6 Evaluation of Retrieved Failed Implants. Responsibilities of Biomedical Engineers -- 9.7 Closing Remarks -- Reference -- Chapter 10 Hydrogels: Promising, Versatile Biomaterials for Implants -- 10.1 Introduction -- 10.1.1 Hydrogel Fundamentals -- 10.1.2 Hydrogel Structure and Network Characterization -- 10.1.3 Equilibrium Swelling Theory -- 10.1.4 Solute Diffusion from Hydrogels -- 10.1.5 Hydrogel Types and Applications -- 10.1.5.1 Microscale Hydrogels -- 10.1.5.2 Nanoscale Hydrogels -- 10.1.5.3 Stimuli-Responsive Hydrogels -- 10.1.5.4 Responsive Hydrogels in Tissue Engineering -- 10.1.6 Development of Three-Dimensional Scaffolds with Fine-Tuned Chemistry, Porosity, and Mechanical Properties.
10.1.7 Growth Factor Retention, Sequestration, and Delivery -- References -- Chapter 11 Biocompatibility: Past, Present, and Future -- References -- Index -- EULA.
Abstract:
Biology and engineering meet in this groundbreaking and growing discipline Biomedical engineering is an established interdisciplinary research and training area, combining various aspects of physiology, biology, materials science and engineering. Biomedical engineering programs and courses are integral parts of pertinent curricula, generating an urgent need for textbooks which can introduce this fundamental subject to new generations of students, researchers and practicing professionals. The textbook Concepts of Tissue-Biomaterial Interactions meets this need with an introduction to the subject. Beginning with various, key, fundamental concepts of cellular biology and the physiology of tissue wound healing (required to understand interactions of tissues and implants) it offers essential information and insight regarding the design of successful biomaterial implants. Concluding with a look at the current forefront and future of the field, it is an indispensable introduction for fundamental and cutting-edge aspects of biomedical engineering applications. Concepts of Tissue-Biomaterial Interactions readers will also find: * Introduction to biological aspects such as cell-extracellular matrix interactions and cell-substrate interactions * Details regarding various aspects of the process of normal tissue wound healing * Current knowledge of tissue wound healing in the presence of implants * Examples of pathological complications, including infection * Design criteria for biocompatible implants * The process of obtaining regulatory approval of new biomaterials and implantable medical devices by pertinent regulatory agencies * Implant biomaterial and medical devices: past, present, and future Concepts of Tissue-Biomaterial Interactions is recommended for advanced undergraduate and for graduate students interested in biomedical engineering, biomaterials, tissue engineering, and implantable biomaterials/medical devices, as well as a reference for practicing biomedical engineering professionals.
Local Note:
John Wiley and Sons
Added Author:
Electronic Access:
https://onlinelibrary.wiley.com/doi/book/10.1002/9781394300013Copies:
Available:*
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