Cover -- Title Page -- Copyright Page -- Contents -- Contributors -- Preface -- Chapter 1 Clinical Pharmacology -- Introduction -- Pharmacokinetics -- Pharmacodynamics -- Inhalant Anesthetics -- Physics of Gases and Vapors -- Control of the Partial Pressure of Delivered Anesthetic -- Minimum Alveolar Concentration -- General Pharmacological Actions of Inhalant Anesthetics -- Clinically Useful Inhalant Anesthetics -- Injectable Anesthetics -- Barbiturates -- Propofol -- Dissociative Anesthetics -- Miscellaneous Anesthetics -- Opioids -- Opioid receptors -- Endogenous Opioid Receptor Ligands

Opioid Receptor Signaling and Mechanisms of Analgesia -- Opioid Receptor Distribution and Therapeutic Implications -- Adverse Effects of Clinically Used Opioids -- Opioid Agonists -- Opioid Agonist-Antagonists and Partial Agonists -- Opioid Antagonists -- Nonsteroidal Anti-inflammatories -- Cyclooxygenases and Prostaglandin Synthesis -- Prostaglandin Receptor Antagonism -- Analgesic and Anti-inflammatory Effects of NSAIDs -- NSAIDs and Fever -- Other Pharmacologic Considerations for NSAID Use -- Contraindications for NSAIDs -- NSAIDs Used in Veterinary Medicine

NSAIDs Not Approved for Use in Veterinary Medicine (Off-label Use) -- Alpha-2 Adrenergic Receptor Agonists and Antagonists -- Introduction -- Alpha-2 Adrenergic Agonist Effects -- Specific Drugs -- Alpha-2 Adrenergic Receptor Antagonists -- Phenothiazines and Butyrophenones -- Introduction -- References -- Chapter2 Analgesia -- Introduction -- Physiology of Pain -- Ascending Nociceptive Pathways -- Antinociceptive Descending Pathways -- Principles of Pain Management -- Pain and its Management in Vertebrate Species -- Fish -- Amphibians -- Reptiles -- Birds -- Mammals -- Pain in Invertebrates

Chapter4 Emergencies and Complications -- Emergency Preparedness -- Environmental Considerations -- Pre-immobilization Plan and Briefing -- Emergency Pack -- Immobilization, Sedation, and Anesthesia -- Inadequate Drug Dosing -- Airway Support -- Unsupported Airway -- Infraglottic Airways -- Supraglottic Airways -- Confirmation of Airway Placement -- Hypoventilation -- Bag Valve Mask -- Demand Valves -- Hypoxemia -- Intranasal and Intratracheal Oxygen Administration -- Oxygen Delivery Equipment -- Cardiovascular Complications and Emergencies -- Bradycardia -- Tachycardia -- Hypotension