Health risk assessment for asbestos and other fibrous minerals

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Title:

Author:

Korchevskiy, Andrey, editor.

ISBN:

9781119438427

9781119438410

9781119438397

Physical Description:

1 online resource

General Note:

Includes index.

Contents:

Part I Hazard Identification -- Chapter 1 Mineralogical Characteristics and Risk Assessment of Elongate Mineral Particles (EMPs): Asbestos, Fiber, and Fragment -- Introduction -- Nomenclature -- Source Specificity: Chemical and Physical Properties -- Source Specificity: Dimension -- Structural Groupings of Common Elongate Minerals -- Establishing the Chemical Composition of Minerals -- Mineral Intergrowths and Associations -- Bioreactivity of Mineral Surfaces: Chemical Factors

The Specificity of Mineral Surfaces: The Example of Quartz -- General Considerations of Solubility -- Formation of Reactive Oxygen Species (ROS) -- Coatings -- Surface Charge -- EMP Surfaces: Chain Silicates and Zeolites -- Physical Factors -- Specific Surface Area -- Enthalpy and Other Thermodynamic Properties -- Density and Aerodynamic Diameter -- Stiffness and Tensile Strength -- The Effects of Heat -- Dimensionality: General Considerations -- Establishing Measurement Protocols -- Optical vs. Electron Microscopy Methods -- Stratified Counting

Sample Preparation for TEM: Direct vs. Indirect Preparation -- Frequency Distributions of Length and Width -- Lung Burden -- Dimensionality and Carcinogenicity -- Discussion -- References -- Chapter 2 Toxicology of Mineral Fibers and Implications for Risk Assessment -- Introduction -- Use of Rodent Models to Analyze the Toxicity to Disease Potential of Naturally Occurring and Synthetic Fibers -- Inhalation Studies -- Intratracheal Instillation and Oropharyngeal Aspiration Studies -- Intrapleural Injection Studies -- Intraperitoneal Injection Studies

Comparative Results on Effects of Asbestos and Other Naturally Occurring Fibers in Rodent Studies -- In vitro Models of Toxicity -- Advantages and Disadvantage of In vitro Models -- Contributions of In vitro Models to Understanding Mechanisms of Cytotoxicity and Carcinogenesis by Mineral Fibers -- Properties of Mineral Fibers Important in Toxicity and Carcinogenic Effects -- A Systems Biology Approach to Understanding Connections and Interactions Between Adverse Outcomes in Mineral Fiber-Induced Diseases -- References

Chapter 3 Health Outcomes of Asbestos Exposure -- A Pathology and Diagnostic Perspective -- Introduction -- Nonmalignant Change in Structure or Function -- Nonmalignant Asbestos-Related Disease -- Pleural -- Asbestos Effusion -- Pleural Plaques and Localized Pleural Thickening (LPT) -- Diffuse Pleural Thickening -- Rounded Atelectasis -- Lung -- Asbestosis -- Malignant Diseases Attributable to Asbestos Exposure -- General Comments -- Asbestos-Related Lung Cancer -- Mesothelioma - Accelerating Knowledge -- References -- Part II Exposure Assessment.

Abstract:

"Asbestos, despite its many modern applications, remains a serious occupational and environmental hazard, and those handling asbestos and other fibrous minerals need a rigorous risk assessment methodology. Written by the leading pioneers of asbestos risk science, Health Risk Assessment for Asbestos and Other Fibrous Minerals provides comprehensive coverage of the basics, theory, models, and practical applications. The science of health risk assessment and other fibrous minerals includes an integration of epidemiology, toxicology, industrial hygiene, and environmental health expertise, as well as coverage on emerging and lesser-known hazards in handling fibrous minerals such as erionite."-- Provided by publisher.

Local Note:

John Wiley and Sons

Subject Term:

Asbestos -- Toxicology.

Hazardous substances -- Health aspects.

Hazardous substances -- Risk assessment.

Risk assessment.

Risk Assessment

Amiante -- Toxicologie.

Substances dangereuses -- Aspect sanitaire.

Évaluation du risque.

Industrial Health & Safety.