This book represents the synthesis of many current cancer theories, which combined, offers a novel and innovative approach in the diagnosis, prevention, and treatment of cancer. It introduces a new and different paradigm in the diagnosis, prevention, and treatment of cancer, by taking into account the organism as a whole, which is very different from the current cellular/tissular approach toward cancer. In this new paradigm, cancer involves dynamic interactions with the entire body and its internal milieu. Focusing on these interactions will permit pre-clinical cancer diagnosis and novel treatment approaches. This onco-holobiont model integrates most of the current malignant process models and it is intended for the use of practitioners/clinicians, cancer researchers, and students with a particular interest in cancer. The goal of this book is to inspire scientists to go beyond the current methods in the treatment of cancer and discover new paradigms.