This book constitutes the refereed proceedings of the 27th International Conference on Enterprise Design, Operations, and Computing, EDOC 2023, held in Groningen, The Netherlands, during October 30-November 3, 2023. The 12 full papers included in this book were carefully reviewed and selected from 36submissions. They were organized in topical sections as follows: Enterprise Modeling, Enterprise Architecture & Engineering, Model-Based Software Engineering, Enterprise Analysis with Process Mining, Process Improvement & Engineering, and Modeling in an Enterprise Context.