This book constitutes the proceedings of the 22nd International Conference on Smart Card Research and Advanced Applications, CARDIS 2023, held in Amsterdam, The Netherlands, during November 14-16, 2023. The 13 full papers presented in this volume were carefully reviewed and selected from 28 submissions. They were organized in topical sections as follows: fault attacks; side-channel analysis; smartcards & efficient Implementations; and side-channel & neural networks.