This textbook provides a comprehensive, thorough and up-to-date treatment of topics of mathematics that an engineer and scientist would need, at the basic levels that contents of engineering and sciences are built by. For this purpose, natural readers would be junior and senior undergraduate students, who normally have the content of this book under different names on their degree plans. Also, engineers and scientists will benefit from this book since the book is a comprehensive volume for such audiences. This book is written in a way that it balances both theory and practical applications of topics from linear algebra, matrix theory, calculus of multivariable, theory of complex variables, several transforms, ordinary and partial differential equations, difference equations, optimization, probability, statistics, theory of reliability and finally, applications from variety of areas of sciences and engineering.