This book reports on engineering methods and technologies for biomedical applications. It covers sensors and devices for biological and medical purposes, along with their fabrication and testing, and advances in engineering technologies, such as autonomous systems, which can support life science and healthcare in the era of industry 4.0. Based on the proceedings of the 4th International Conference for Innovation in Biomedical Engineering and Life Sciences, ICIBEL 2022, held on December 10-13, 2022, in Kuala Lumpur, Malaysia, this book provides researchers and professionals with a timely snapshot of current issues and challenges in the broad field of biomedical engineering. It is aimed at inspiring future research and fostering interdisciplinary and international collaborations in this field and relating ones.