This proceedings presents papers from the Second International Adaptive and Sustainable Science, Engineering and Technology Conference (ASSET 2023), which took place simultaneously in Manchester, UK and Ikot Akpaden, Nigeria on 18-20, July 2023. The ASSET conference serves as an interactive forum for the advancement of the practice of adaptive and sustainable systems across the multiple disciplines and specialty areas involved with the science, engineering, and technology of integrated entities, complex systems, and networks. The conference provides an avenue for practitioners, researchers, managers, developers, analysts, educators, and users to exchange innovative ideas, concepts, applications, and lessons learned in addressing domain-specific problems, applications-oriented topics, methodologies, standards and multidisciplinary research opportunities and findings relating to ASSET systems.