This 4-volume CCIS post-conference set represents the proceedings of the Second International Conference on Advances in Smart Computing and Information Security, ASCIS 2023, in Rajkot, Gujarat, India, December 2023. The 91 full papers and 36 short papers in the volume were carefully checked and selected from 432 submissions. Various application areas were presented at the conference, including healthcare, agriculture, automotive, construction and engineering, pharmaceuticals, cybercrime and sports.