This book explores Mechanical Integrity (MI) and Risk-Based Inspection (RBI) methodologies, specifically tailored for professionals in chemical, petrochemical, and petroleum refining plants. It starts with foundational aspects of equipment and pipe design and manufacturing within the process industry, followed by an introduction to prevalent damage mechanisms in metal components during service. The book then delves into the general methodology for mechanical integrity analysis, covering remaining life estimation and methods for assessing common defects found in in-service components. It further introduces the principles and overall methodology of Risk-Based Inspection, detailing approaches for evaluating Probability of Failure and Consequences, along with the application of risk matrices to formulate Inspection-Based Risk (IBR) plans. Lastly, it directs attention to the practical implementation of MI and IBR methodologies for managing the integrity of pipelines transporting liquid and gaseous hydrocarbons, aligned with API codes and ASME standards, offering a comprehensive example illustrating the development of an integrity management plan for a real-life pipeline. Through this structured approach, professionals can gain actionable strategies and insights essential for ensuring the safety and reliability of industrial plants and pipelines.