South Africa boasts high biodiversity among its flora and this is associated with many undiscovered medicinal plants with therapeutic potential. To target this untapped resource, the first step is to introduce these species to a wider spectrum of audience, be they the academics who carry out research, students interested in holistic medicine and healing, or those working in the natural product industry. In this work, we document a list of medicinal plants from Sub-Saharan Africa that have been underestimated in their therapeutic value and not thoroughly studied. Our book contains the recent scientific studies and validation on the individual plants. Written and organised in an easily accessible way, each entry includes specific information on the plant's distribution, traditional usage and their phytochemical content. In summary, this book introduces new and exciting plants of Sub-Saharan Africa in a comprehensive and well-thought-out format for academia, pharmacists, clinicians, complementary and alternative medicine practitioners, traditional healers, industry and the general experienced or novice botanist.