The two-volume set, LNAI 15246 and 15247, constitutes the proceedings of the 23rd Mexican International Conference on Artificial Intelligence, MICAI 2024, held in Tonantzintla, Mexico in October 21-25, 2024. The 37 full papers presented in these proceedings were carefully reviewed and selected from 141 submissions. The papers presented in these two volumes are organized in the following topical sections: Part I - Machine Learning; Computer Vision. Part II - Intelligent Systems; Bioinformatics and Medical Applications; Natural Language Processing.