This two-volume set constitutes the refereed proceedings of the Second International Conference, ISDS 2024, held in Nha Trang, Vietnam, during November 9-10, 2024. The 38 full papers and 10 short papers were carefully reviewed and selected from 129 submissions. They were categorized under the topical sections as follows: AI in E-Commerce, Agriculture, and Aquaculture; AI in Health Care Analytics; Big Data, IoT, and Cloud Computing; and Natural Language Processing.