This book provides crucial insights into the most recent advancements in understanding pathophysiology of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), and presents innovative treatment approaches. The emerging areas of study and potential avenues for further investigation are discussed in chapters. Additionally, the latest information on diagnostic tools, lifestyle interventions, and pharmacological treatments is also presented. With the worldwide prevalence of MASLD on the rise, it helps to equip medical professionals (hepatologists, gastroenterologists, endocrinologists, cardiologists, nephrologists, internists, and surgeons), researchers, and patients with up-to-date knowledge to effectively combat this multifaceted condition.