This book is the first authoritative and comprehensive manual dedicated to left atrial appendage closure (LAAC). It provides an up-to-date and highly illustrated synopsis of the pre-, post- and peri-procedural approach for a state of the art contemporary approach for LAAC, and clinical applications of LAAC and its role in the treatment for Atrial Fibrillation. It relays to the reader a contemporary view of the emerging interplay between LAAO and atrial fibrillation. In addition, this manual discusses the clinical implications and therapeutic targets of LAAC in atrial fibrillation and increased risk for bleeding. A Contemporary Manual of Left Atrial Appendage Closure is an essential resource for physicians, residents, fellows, and medical students in cardiology, internal medicine, primary care, and health promotion and disease prevention.