This book aims to propose a suitable contingency plan that can minimize the negative effects of future health crises while strengthening the resilience and adaptability of SMEs. This work is part of an integrated approach from the laboratory to the market, with the aim of analyzing and promoting practical and strategic solutions for the development of small and medium-sized enterprises (SMEs) in a crisis context. Following the results obtained, the scientific research team sought to broaden its scope of investigation by addressing the challenges that SMEs face during global crises. This is a crucial issue in a context where economic sustainability and security are increasingly threatened by unforeseen events such as global epidemics.