This book constitutes the refereed revised selected papers of the 11th Latin American Conference on High Performance Computing, CARLA 2024, held in Santiago de Chile, Chile, during September 30-October 4, 2024. The 21 full papers included in this book were carefully reviewed and selected from 42 submissions. They were organized in topical sections as follows: High Performance Computing Track; Artificial Intelligence at HPC Scale Track; High Performance Computing Applications Track.