This book constitutes the refereed proceedings of the 24th International Conference on Mathematical Modeling and Supercomputer Technologies , MMST 2024, held in Nizhni Novgorod, Russia, during November 18-21 2024. The 17 full papers and 3 short papers included in this book were carefully reviewed and selected from 39 submissions. They were organized in topical sections as follows: artificial intelligence and supercomputer simulation; computing in optimization and optimal control; computational methods for mathematical models analysis.