This volume LNCS 13855 book constitutes the refereed proceedings of the 12th International Workshop on Socio-Technical Aspects in Security and Trust, STAST 2022, which held in Copenhagen, Denmark, during September 26, 2022. The 6 regular papers and 2 short papers were carefully reviewed and selected from 20 submissions for inclusion in the book. The workshop focused especially on the interplay of technical and human factors in achieving or breaking computer security, privacy, and trust, in both organizational and individual settings.