This book constitutes the refereed proceedings of the 11th International Symposium on From Data to Models and Back, DataMod 2023, held in Eindhoven, The Netherlands during November 6-7, 2023. The 8 full papers presented were carefully reviewed and selected from 10 submissions. They were organized in topical sections as follows: domain-specific modeling and analysis; system biology; formal methods in healthcare; and natural language processing.