This volume in the Cell Biology and Translational Medicine series continues to explore the potential utility of stem cells in regenerative medicine. Topics covered include various aspects of stem cells in regeneration, both in health and cancer. These include research into microenvironments, signals, exosomes, biomaterials and their role in regeneration in general and in various types of cancer. A goal of the series continues to be to highlight timely, often emerging topics and novel approaches that can accelerate the utility of stem cells in regenerative medicine.