This book is intended for professionals who must deal with telemedicine having little or no knowledge of matrix algebra and matrix calculus, and little or no knowledge of higher mathematics with special reference to differential equations: no other books cover these topics starting from scratch. It would therefore fill the gap existing between very simple and elementary textbooks and much more complicated ones, mainly adopting mathematical and on engineering approaches. Aims and objectives of this volume are to provide non-mathematicians and non-physicists with an almost complete coverage of the topic, from calculus and linear algebra to matrix derivatives, hat matrices, and regression models, as well as to give basic information about the description of a system by means of differential equations, which will be useful for a deeper understanding of telemedicine. The book is mainly addressing postgraduate students in medicine, biology, biostatistics, but it would also be a very useful tool researchers in other fields of a medical/biomedical curriculum.