This volume LNCS 15276 constitutes the revised selected papers of the 19th International Meeting on Computational Intelligence Methods for Bioinformatics and Biostatistics, CIBB 2024, held in Benevento, Italy, during September 4-6, 2024. The 24 full papers and 3 short papers were carefully reviewed and selected from 28 submissions. They were organized in the following topical sections: Bioinformatics; Medical Informatics; Natural Language Processing (NLP) and Large Language Models (LLM) for Unstructured Data in Health Informatics; Modeling and Simulation Methods for Computational Biology and Systems Medicine; Machine Learning for Structured Data in Clinical Informatics and Medical Biology; Computational Intelligence in Personalized Medicine; and Computational Structural Bioinformatics.