This book comprises original and peer reviewed research papers presented at 2025 17th International Conference on Machine Learning and Computing that was held in Guangzhou, China, from February 14 to 17, 2025. The focus of the conference is to establish an effective platform for institutions and industries to share ideas and to present the works of scientists, engineers, educators and students from all over the world. Topics discussed in this volume include Machine Learning Theory and Algorithms, High-performance Computing Models and Data Processing, Large-scale Language Models and Natural Language Processing, Data-oriented Information System Optimization and Intelligent Computing, AI-based Intelligent Control Systems and System Security, etc. The book will become a valuable resource for academics, industry professionals, and engineers working in the related fields of machine learning and computing.