This book provides latest insights into the clinical significance of glycans, the role that glycans play in the etiology and for the course of inborn and acquired diseases and new glycan-based therapeutics and vaccines. Furthermore, the book provides highly topical insights into the analysis and synthesis of complex carbohydrates, and outlines why proper glycosylation is a key factor for the design and the manufacturing of therapeutic antibodies, other therapeutic glycoproteins and vaccination. .