Quantitative Systems Pharmacology as a discipline has matured over the past decade and is being used more frequently in academia and industry; however, dedicated training programs and courses are limited. This book will provide a go-to educational reference for a broad audience with topics including: the technology's history, comparisons to other modeling methods and emerging opportunities to bring methods together, best practice for implementation illustrated by real-world examples, and finally a summary of where the technology is headed in the future.