This book constitutes the thoroughly refereed post-conference proceedings of the Second International Conference on Mobile, Secure and Programmable Networking, held in Paris, France, This book constitutes the thoroughly refereed post-conference proceedings of the Second International Conference on Mobile, Secure and Programmable Networking, held in Paris, France, in June 2016. The 17 papers presented in this volume were carefully reviewed and selected from 37 submissions. They discuss new trends in networking infrastructures, security, services and applications while focusing on virtualization and cloud computing for networks, network programming, software defined networks (SDN) and their security.