This book constitutes the refereed proceedings of the 16th Industrial Conference on Advances in Data Mining, ICDM 2016, held in New York, NY, USA, in July 2016. The 33 revised full papers presented were carefully reviewed and selected from 100 submissions. The topics range from theoretical aspects of data mining to applications of data mining, such as in multimedia data, in marketing, in medicine, and in process control, industry, and society.