This volume constitutes the refereed proceedings of the 11th International Conference on Hybrid Artificial Intelligent Systems, HAIS 2016, held in Seville, Spain, in April 2016. The 63 full papers published in this volume were carefully reviewed and selected from 150 submissions. They are organized in topical sections on data mining and knowledge discovery; time series; bio-inspired models and evolutionary computation; learning algorithms; video and image; classification and cluster analysis; applications; bioinformatics; and hybrid intelligent systems for data mining and applications.