This two volume set LNCS 10039 and 10040 constitutes the refereed post-conference proceedings of the Second International Conference on Cloud Computing and Security, ICCCS 2016, held in Nanjing, China, during July 29-31, 2016. The 97 papers of these volumes were carefully reviewed and selected from 272 submissions. The papers are organized in topical sections such as: Information Hiding, Cloud Computing, Cloud Security, IOT Applications, Multimedia Applications, Multimedia Security and Forensics.