This 2-volume set constitutes the refereed proceedings of the 4th International Conference on HCI in Business, Government and Organizations, HCIBGO 2017, held as part of the 19 International Conference on Human-Computer Interaction , HCII 2017, which took place in Vancouver, Canada, in July 2017. HCII 2017 received a total of 4340 submissions, of which 1228 papers were accepted for publication after a careful reviewing process. The 31 papers presented in this volume, focusing on interacting with information systems, are organized in topical sections named: human-centered design in information systems; information systems in healthcare, learning, cultural heritage and government; novel interaction devices and techniques;.