This book constitutes the thoroughly refereed proceedings of the 12th International Conference on Information and Communication Technologies in Education, Research, and Industrial Applications, ICTERI 2016, held in Kyiv, Ukraine, in June 2016. The 10 revised full papers presented together with one invited keynote paper were carefully reviewed and selected from 122 submissions. The papers are grouped into topical sections on invited paper; advances in ICT research; ICT in education.