ch. 1. Mechanisms of antisense drug action, an introduction / Stanley T. Crooke ... [et al.] -- ch. 2. The RNase H mechanism / Walt Lima, Hongjiang Wu, and Stanley T. Crooke -- ch. 3. Small RNA silencing pathways / Alla Sigova and Phillip D. Zamore -- ch. 4. Splice switching oligonucleotides as potential therapeutics / Peter Sazani, Maria A. Graziewicz, and Ryszard Kole -- ch. 5. Basic principles of antisense drug discovery / Susan M. Freier and Andrew T. Watt -- ch. 6. The medicinal chemistry of oligonucleotides / Eric E. Swayze and Balkrishen Bhat -- ch. 7. Basic principles of the pharmacokinetics of antisense oligonucleotide drugs / Arthur A. Levin, Rosie Z. Yu, and Richard S. Geary -- ch. 8. Routes and formulations for delivery of antisense oligonucleotides / Gregory E. Hardee, Lloyd G. Tillman, and Richard S. Geary -- ch. 9. Liposomal formulations for nucleic acid delivery / Ian MacLachlan -- ch. 10. Pharmacological properties of 2'-O-methoxyethyl-modified oligonucleotides / C. Frank Bennett -- ch. 11. Pharmacokinetic/pharmacodynamic properties of phosphorothioate 2'-O-(2-methoxyethyl)-modified antisense oligonucleotides in animals and man / Richard S. Geary ... [et al.] -- ch. 12. Toxicologic properties of 2'-O-methoxyethyl chimeric antisense inhibitors in animals and man / Scott P. Henry ... [et al.] -- ch. 13. An overview of the clinical safety experience of first- and second-generation antisense oligonucleotides / T. Jesse Kwoh -- ch. 14. Manufacturing and analytical processes for 2'-O-(2-methoxyethyl)-modified oligonucleotides / Daniel C. Capaldi and Anthony N. Scozzari -- ch. 15. Utilizing chemistry to harness RNA interference pathways for therapeutics : chemically modified siRNAs and antagomirs / Muthiah Manoharan and Kallanthottathil G. Rajeev --

ch. 16. Discovery and development of RNAi therapeutics / Antonin R. deFougerolles and John M. Maraganore -- ch. 17. Optimization of second-generation antisense drugs : going beyond generation 2.0 / Brett P. Monia ... [et al.] -- ch. 18. Modulating gene function with peptide nucleic acids (PNA) / Peter E. Nielsen -- ch. 19. Locked nucleic acid / Troels Koch and Henrik ¿rum -- ch. 20. Morpholinos / Patrick L. Iversen -- ch. 21. Potential therapeutic applications of antisense oligonucleotides in ophthalmology / Lisa R. Grillone and Scott P. Henry -- ch. 22. Cardiovascular therapeutic applications / Rosanne Crooke, Brenda Baker, and Mark Wedel -- ch. 23. Developing antisense drugs for metabolic diseases : a novel therapeutic approach / Sanjay Bhanot -- ch. 24. Inflammatory diseases / Susan A. Gregory and James G. Karras -- ch. 25. Antisense oligonucleotides for the treatment of cancer / Boris A. Hadaschik and Martin E. Gleave -- ch. 26. Targeting neurological disorders with antisense oligonucleotides / Richard A. Smith and Timothy M. Miller -- ch. 27. Mechanisms and therapeutic applications of immune modulatory oligodeoxynucleotide and oligoribonucleotide ligands for toll-like receptors / Jr̲g Vollmer and Arthur M. Krieg -- ch. 28. Aptamer opportunities and challenges / Charles Wilson.