Title:
Bioactive compounds from natural sources natural products as lead compounds in drug discovery
Author:
Tringali, Corrado, 1950-
ISBN:
9781439870662
Edition:
2nd ed.
Publication Information:
Boca Raton : CRC Press, 2012.
Physical Description:
xv, 622 p., [10] p. of plates : ill. (some col.).
Contents:
ch. 1. Strategies and methods for a sustainable search for bioactive compounds / Lars Bohlin ... [et al.] -- ch. 2. Discovery of potential anticancer agents from aquatic cyanobacteria, filamentous fungi, and tropical plants / Jimmy Orjala ... [et al.] -- ch. 3. Metabolic engineering of natural product biosynthesis / Xinkai Xie, Kangjian Qiao, and Yi Tang -- ch. 4. Computational approaches for the discovery of natural lead structures / Judith M. Rollinger and Gerhard Wolber -- ch. 5. Recent advances in the application of electronic circular dichroism for studies of bioactive natural products / Nina Berova ... [et al.] -- ch. 6. Natural products as treatments for and leads to active compounds in viral diseases / David J. Newman and Gordon M. Cragg -- ch. 7. Natural products as inhibitors of hypoxia-inducible factor-1 / Dale G. Nagle and Yu-Dong Zhou -- ch. 8. Antitumor or wound healing actions of natural products through inhibiting or enhancing angiogenesis / Yoshiyuki Kimura -- ch. 9. From natural polyphenols to synthetic antitumor agents / Carmela Spatafora and Corrado Tringali -- ch. 10. Resveratrol against major pathologies : from diet prevention to possible alternative chemotherapies with new structural analogues / Norbert Latruffe ... [et al.] -- ch. 11. Drug discovery from natural substances : a case study : camptothecins / Gabriele Fontana and Lucio Merlini -- ch. 12. Plant compounds and derivatives as inhibitors of cancer cell multidrug resistance / Virginia Lanzotti ... [et al.] -- ch. 13. Recent advances in the search of novel calmodulin inhibitors from selected Mexican plants and fungi / Rachel Mata ... [et al.] -- ch. 14. Neuroprotective effects of natural products from traditional Chinese herbs / Hai Yan Zhang and Xi Can Tang -- ch. 15. Drugs for the neglected disease malaria based on natural products / S. Brg̜ger Christensen and Ib Christian Bygbjerg -- ch. 16. Endophytic microorganisms as a source of bioactive compounds / Yoshihito Shiono and Ken-ichi Kimura -- ch. 17. Biologically active natural products from Australian marine organisms / Robert J. Capon.
Abstract:
"The first edition of Bioactive Compounds from Natural Sources was published in a period of renewed attention to biologically active compounds of natural origin. This trend has continued and intensified--natural products are again under the spotlight, in particular for their possible pharmacological applications. Largely focusing on natural products as lead compounds in drug discovery, Bioactive Compounds from Natural Sources, Second Edition: Natural Products as Lead Compounds in Drug Discovery is actually a completely new volume containing surveys of selected recent advances in an interdisciplinary area covering chemistry of natural products, medicinal chemistry, biochemistry, and other related topics.Written by some of the most reputed scientists in the field, this second edition includes new chapters from authors who contributed to the first edition as well as many chapters compiled by new authors. Introducing the reader to strategies and methods in the search for bioactive natural products, this book covers topics including:Natural sources of bioactive compounds such as aquatic cyanobacteria, filamentous fungi, and tropical plants,The tremendous potentiality of metabolic engineering of natural products biosynthesis The contribution of emerging or developing technologies to the study of bioactive natural compounds, namely computational methods and circular dichroism The potential of natural or natural-derived compounds for specific therapeutic applications: treatment of viral diseases, regulation of hypoxia-inducible factor, antimalarials, modulation of angiogenesis, and antitumor and wound-healing activitySelected examples of natural product families and related synthetic analogues, namely polyphenols and campthotecinsCompiled for researchers and Ph.D. students working in interdisciplinary fields, this book will also be appreciated by readers without a background in chemistry interested in bioactive natural products, their biological and pharmacological properties, and their possible use as chemopreventive or chemotherapeutic agents. Conversely, the biological and pharmacological data and methods are accessible by chemists"-- Provided by publisher.
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