Title:
Adaptive and flexible clinical trials
Author:
Chin, Richard.
ISBN:
9781439838334
Publication Information:
Boca Raton, Fla. : CRC Press, 2012.
Physical Description:
xiii, 184 p. : ill.
Contents:
1. Background -- 2. Conventional statistics -- 3. Statistics used in adaptive clinical trials -- 4. Specific requirements for adaptive trials -- 5. Adaptive randomization and allocation -- 6. Sample size reestimation -- 7. Traditional dosing -- 8. Adaptive dosing -- 9. Interim analysis and adaptive termination of study and study arms -- 10. Adaptive changes in study design and decision rules -- 11. Seamless designs and adaptive clinical trial conduct -- 12. Analysis and interpretation of results.
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