History -- Basic Principles. Cryobiology -- Immunocryosurgery -- Techniques -- Basic Equipments -- Cryobiopsy -- Common Benign Lesions -- Vascular Lesions -- Pre Malignant Management. Combination Treatments -- Malignant Lesions -- Bcc and Ultrasound -- Special Areas: Eyelids, Earlobe, Nose -- Cryosurgery and other Imaging Techniques -- Palliative  Treatment -- Postoperative Care -- Complications -- Future considerations.