Part I General Aspects: Sexual Ambiguity: Development Of Judgement And Evaluation Criteria Over The Centuries -- Gender dysphoria: definition and evolution through the years -- The DSM Diagnostic Criteria For Gender Dysphoria -- Epidemiologic Considerations On Transsexualism -- Etiopathogenetic Hypotheses Of Transsexualism -- Imaging: Examination Technique -- Clinical Management Of Gender Dysphoria In Adolescents -- Part II Management of Male to Female: Psychological Characteristics And Sexuality Of Natal Males With Gender Dysphoria -- Endocrine Treatment Of Transsexual Male To Female Persons -- Surgical Therapy: My Personal Technique -- Surgical Therapy: Vaginoplasty In Male Transsexuals Using Penile Skin And Urethral Flap -- Surgical Therapy: Construction Of The Neovagina Using The Pelvic Peritoneum -- Surgical Therapy: Technical Suggestions For Better And Lasting Functional And Aesthetic Outcomes In Manufacturing The Neoclitoris -- Surgical Therapy: Feminization Laryngoplasty -- Surgical Therapy: Mastoplasty -- Complications Of Male To Female Vaginoplasty -- Surgery In Complications: Colon Vaginoplasty -- Surgery In Complications: Ileal Vaginoplasty -- Surgery In Complications: Management Of Prolapse -- Evaluation Of Lower Urinary Tract Function After Surgery -- Follow Up Of Patients After Male To Female (Mtf) Sex Reassignment Surgery (Srs) -- Quality Of Life After Sexual Reassignment Surgery -- Imaging -- Part III Management Of Female To Male: The Hot Questions In Prepubertal Gender Dysphoria In Girls -- The Female-To-Male Medical Treatment -- Surgical Therapy: Pedicle Anterolateral Thigh Flap -- Surgical Therapy: Free Forearm Flap -- Surgical Therapy: Metoidioplasty Technique And Results -- Surgical Therapy: Phalloplasthy With Suprapubic Flap-Pryor's Technique -- Surgical Therapy: Total Phalloplasty Using Latissimus Dorsi Flap -- Surgical Therapy: Chest Wall Contouring For Female-To-Male Transsexuals -- Surgical Therapy: Possible One Step Solutions -- SurgicalTherapy: Scrotal Reconstruction In Female-To-Male Transsexuals -- Complications -- Penile Prosthesis Implantation In Phalloplasty In Female To Male Transsexuals -- Imaging -- Part IV Legislative, Ethical And Health Policy Aspects: Ethical Issues For The Practitioner Work In The Transgender Care -- Transgender Identity And Sexually Transmitted Diseases Including HIV -- Answers To Fertility Request.