Part 1 Clinical reasoning -- 1. Background knowledge -- 2. Decision on diagnosis: what is the problem? -- 3. Decision on etiology: what caused the problem? -- 4. Decision on prognosis: what can be achieved? -- 5. Decision on therapy: what can we do about the problem? -- Part 2 Evidence-based practice -- 6. Clinical reasoning and evidence-based practice -- 7. What is the problem: how to appraise scientific articles on diagnostic tests? -- 8. What caused the problem: how to appraise scientific articles on etiological factors? -- 9. What can be achieved: how to appraise scientific articles on prognostic research? -- 10. What can we do about the problem: how to appraise scientific articles on interventions? -- 11. How to reach a better understanding of the patients' perspective: reading and appraising qualitative research -- Part 3 Extra's -- Chapter 12. Deepen your knowledge -- Chapter 13. Education about clinical reasoning and evidence-based practice.