Part I. Hypoxic, High-Altitude, and Extreme Stress: Health Implications and Interventions -- Chapter 1. Stress and Adaptogens -- Chapter 2. Molecular Basis of Response to Hypoxia -- Chapter 3. Activation of the Hypoxia-Inducible Factor under High Altitude Stress -- Chapter 4. Regulation of Vascular Endothelial Growth Factor by SUMOylation in Hypoxic Cardiomyocytes -- Chapter 5. Expression of Vascular Endothelial Growth Factor at High Altitude -- Chapter 6. Thrombogenetic Risk at High Altitude: Early Diagnosis and Treatment Modalities -- Chapter 7. Leaky Gut at High Altitude: Synbiotics May be a Possible Solution -- Chapter 8. Human Gastrointestinal Tract: Impact of Hypobaric Hypoxia -- Chapter 9. Mechanism of Skeletal Muscle Atrophy at High Altitude: Role of Herbals and Nutraceuticals -- Chapter 10. Altitude Acclimatization via Pharmacological and Non-Pharmacological Interventions -- Chapter 11. Performance Enhancement under Extreme Stressful Environment -- Chapter 12. Military Footwear and Extreme Environment Operations: An Ergonomics Perspective -- Chapter 13. Therapeutic Significance of Tanshinone: Pathophysiology and Disruptive Technologies -- Chapter 14. Acclimatization: A Way to Cope-up with a Stressful Environment -- Part II. Oxidative & Genotoxic Stress: Health Implications and/or Approaches to Management -- Chapter 15. Genotoxin Stress and the Role of Alkaloids -- Chapter 16. Cellular Stress, Survival Mechanism, and Adaptation -- Chapter 17. Malnutrition-Induced Oxidative Stress in the Nervous System and Its Health Implications -- Chapter 18. Oxidative Medicine & Novel Pharmacological Treatment Approaches in Liver Disease -- Chapter 19. Sleep, Brain, and Stress -- Chapter 20. Senolytics in Brain Disorders - A Novel Pharmacological Approach to Control Cellular Senescence and Oxidative Stress -- Part III. Stress Management through Dietary Modifications and Nutritional Interventions -- Chapter 21. Prevention of Pro-Inflammatory Markers by Medicinal Mushrooms Under Stressful Environment -- Chapter 22. Nutraceuticals in Alleviating Aging -- Chapter 23. Heat Stress and Dehydration -- Chapter 24. Management of Stress through Dietary Modifications -- Chapter 25. Dietary Modifications to Manage Stress. .