PART I A NEW CONCEPT OF NEURODEGENERATION IN BIOLOGY AND PATHOPHYSIOLOGY -- 1 Conformational disease and RNA disease theory in the context of neurodegenerative diseases -- 2 Brain-peripheral organ communication -- 3 The brain-immune network in spinal cord injury -- PART II CHANGES IN CLINICAL EVALUATION AND NEW BIOMARKERS -- 4 Renovation of clinical evaluation and new biomarkers -- 5 Clinical Systems Neuroscience -- PART III RISK FACTORS IN NEURODEGENERATION -- 6 Genetic risk factors for neurodegenerative diseases -- 7 Intermediate phenotypes approach for neuropsychiatric disorders -- PART IV FUTURE DIRECTIONS FOR THERAPY -- 8 Significance of mechanism-oriented research toward neuronal protection therapy against neurodegenerative disorders ~ ZNRF1 E3 ubiquitin ligase as a critical mediator for Wallerian degeneration and neuronal apoptosis -- 9 Drug development for neurodegenerative diseases -- 10 Physical therapy and rehabilitation in patients with degenerative cerebellar diseases: current evidence and future direction -- 11 Home- and Community-based medical care for neurodegenerative diseases -ALS as an illustration- -- PART V HEALTH PROMOTION: PREVENTION AND QUALITY OF LIFE -- 12 Information Environment and Brain Function: A New Concept of the Environment for the Brain -- 13 Social Implementation of Neurodegenerative Disease Research and Neuroethics.-.