part Section I Scientific Foundations -- chapter 1 Pathophysiological Mechanisms of Seizures and Epilepsy: A Primer / chapter 2 Blood–Brain Barrier, Blood Flow, Neoplasms, and Epilepsy: The Role of Astrocytes / chapter 3 Metabolic Regulation of Seizures and Epileptogenesis / chapter 4 Brain Inflammation and Epilepsy / chapter 5 Drug Resistance in Epilepsy and Status Epilepticus / chapter 6 Epilepsy with Complex Genetics: Looking Beyond the Channelopathies / chapter 7 Pathophysiology of Developmental Epilepsies / part Section II Antiepileptic Drugs -- chapter 8 Mechanisms of Antiepileptic Drug Action / chapter 9 Epilepsy and Disease Modification: Animal Models for Novel Drug Discovery / chapter 10 1Chapter 0 Pharmacogenetics of AED Development / chapter 11 1Chapter 1 Neuroprotective Strategies Using Antiepileptic Drugs / chapter 12 1Chapter 2 Posttraumatic Seizures and Epileptogenesis: Good and Bad Plasticity / chapter 13 1Chapter 3 Possible Roles of Nonsynaptic Mechanisms in Synchronization of Epileptic Seizures: Potential Antiepileptic Targets? / chapter 14 1Chapter 4 A Mechanistic Approach to Antiepileptic Drug Interactions / part Section III Epilepsy Surgery -- chapter 15 1Chapter 5 Advances in Structural and Functional Neuroimaging: How Are These Guiding Epilepsy Surgery? / chapter 16 1Chapter 6 Magnetoencephalography in Clinical Epilepsy: A Translational Viewpoint / chapter 17 1Chapter 7 What Have We Learned from Resective Surgery in Pediatric Patients with Cortical Dysplasia? / chapter 18 1Chapter 8 Nonsurgical Ablation for Epilepsy / chapter 19 1Chapter 9 Deep Brain Stimulation for Epilepsy / chapter 20 2Chapter 0 Optical Imaging Techniques in Pediatric Neocortical Epilepsy / chapter 21 2Chapter 1 High-Frequency Oscillations in Epileptic Brain / part Section IV Alternative Therapies -- chapter 22 2Chapter 2 Special Treatments in Epilepsy / chapter 23 2Chapter 3 Herbs and Botanicals / chapter 24 2Chapter 4 The Ketogenic Diet: Scientic Principles Underlying Its Use / chapter 25 2Chapter 5 Vagus Nerve Stimulation / chapter 26 2Chapter 6 Antiinammatory Treatments for Seizure Syndromes and Epilepsy / part Section V Other Modulators of the Epileptic State -- chapter 27 2Chapter 7 Impact of Neuroendocrine Factors on Seizure Genesis and Treatment / chapter 28 2Chapter 8 Neurosteroid Replacement Therapy for Catamenial Epilepsy / chapter 29 2Chapter 9 Chronobiology and Sleep: Implications for Seizure Propensity / chapter 30 3Chapter 0 Pediatric Epilepsy: A Developmental Neuropsychiatric Disorder / part 3Chapter 1 Novel Mechanisms of Drug Delivery -- chapter 31 Novel Mechanisms of Drug Delivery / chapter 32 3Chapter 2 Early Seizure Detection: Considerations and Applications / chapter 33 Gene and Stem Cell Therapies for Treating Epilepsy / chapter 34 Arresting Epileptogenesis: The Current Challenge