section I. Carcinomas of unknown primary site : several things we know for sure -- section II. Diagnostic evaluation in carcinomas of unknown primary site : what shall we do and when shall we stop seeking the primary site? -- section III. Emerging diagnostic tools -- section IV. Prognostic factors -- section V. Systemic chemotherapy -- section VI. Local treatments in carcinoma of unknown primary site : is it relevant? -- section VII. The biology of carcinoma of unknown primary site -- section VIII. Quality of life and psychosocial aspects -- section IX. Clinical cases of carcinoma of unknown primary site.