History and Evolution of Intrathecal Drug Delivery -- Intraspinal Anatomy: Considerations in Intrathecal Drug Delivery -- Spinal Target Receptors in Intrathecal Drug Delivery -- Mechanisms of Action of Intrathecally Administered Agents -- Physicochemical Properties and Compounding of Intrathecally Administered Agents -- Cerebrospinal Fluid Flow Dynamics -- Uptake and Distribution of Intrathecally Administered Agents -- Animal Models of Intrathecal Drug Delivery: Clinical Correlates -- Intrathecal Drug Delivery for Pain: Medical Considerations -- Intrathecal Drug Delivery for Pain: Psychological Considerations -- Intrathecal trialing Techniques for Pain Indications -- Catheter Localization and Programming Parameters for Pain -- Maintenance and Troubleshooting of Intrathecal Therapy for Pain -- Intrathecal Agents: Choices for Pain -- Intrathecal Therapy for Cancer Pain: Best Practices -- Intrathecal Therapy for Non-Cancer Pain: Best Practices -- Managing Complications of Intrathecal Therapy for Pain -- Assessing Patients with Movement Disorders for Intrathecal Therapy -- Trialing Techniques for Spasticity -- Catheter Localization and Programming Parameters for Spasticity -- Intrathecal Agents Use for Spasticity -- Maintenance and Troubleshooting of Intrathecal Therapy for Spasticity -- Managing Complications of Intrathecal Therapy for Spasticity -- System Choices -- Implantation Techniques -- Preoperative Considerations -- Managing Surgical Complications -- ;Special Patient Populations (Children, Anticoagulation, Other implanted devices) -- Cost Effectiveness of Intrathecal Drug Delivery -- Keys to Managing a Successful Targeted Drug Delivery Practice -- Targeted Drug Delivery: Beyond the Spinal Canal.