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Cover image for Flow and microreactor technology in medicinal chemistry
Title:
Flow and microreactor technology in medicinal chemistry
Author:
Alza, Esther, editor.
ISBN:
9783527824595

9783527824618
Physical Description:
1 online resource.
Series:
Methods and principles in medicinal chemistry ; volume 81

Methods and principles in medicinal chemistry ; v. 81.
General Note:
Includes index.
Contents:
Front Matter -- Flow Chemistry at the Extremes: Turning Complex Reactions into Scalable Processes / Andrew R Bogdan -- Automated Flow Chemistry Platforms / Juan A Rincón, María José Nieves-Remacha, Carlos Mateos -- Flow Chemistry Opportunities for Drug Discovery / María Lourdes Linares, Enol López, Eduardo Palao, Jesús Alcázar -- Flow Chemistry in Medicinal Chemistry: Applications to Bcr - Abl Kinase Inhibitors / Paul Richardson -- Integrated Systems for Continuous Synthesis and Biological Screenings / Antimo Gioiello, Giada Moroni, Bruno Cerra -- Application of Continuous-Flow Processing in Multistep API and Drug Syntheses / Faith M Akwi, Paul Watts -- Continuous-Flow Multistep Synthesis of Active Pharmaceutical Ingredients / Yuesu Chen, Jean-Christophe M Monbaliu -- Enantioselective (Bio)Catalysis in Continuous-flow as Efficient Tool for the Synthesis of Advanced Intermediates and Active Pharmaceutical Ingredients / Laura Amenós, Anna M Sobolewska, Esther Alza, Miquel A Pericàs -- Innovative Process Development of Pharmaceutical Intermediates Under Continuous-Flow System / Koji Machida, Hiroaki Yasukouchi -- Index
Abstract:
Learn to master a powerful technology to enable a faster drug discovery workflow The ultimate dream for medicinal chemists is the ability to synthesize new drug-like compounds with the push of a button. The key to synthesizing chemical compounds more quickly and accurately lies in computer-controlled technologies that can be optimized by machine learning. Recent developments in computer-controlled automated syntheses that rely on miniature flow reactors--with integrated analysis of the resulting products--provide a workable technology for synthesizing new chemical substances very quickly and with minimal effort. In Flow and Microreactor Technology in Medicinal Chemistry, early adopters of this ground-breaking technology describe its current and potential uses in medicinal chemistry. Based on successful examples of the use of flow and microreactor synthesis for drug-like compounds, the book introduces current as well as emerging uses for automated synthesis in a drug discovery context. Flow and Microreactor Technology in Medicinal Chemistry readers will also find: Numerous case studies that address the most common applications of this technology in the day-to-day work of medicinal chemists How to integrate flow synthesis with drug discovery How to perform enantioselective reactions under continuous flow conditions Flow and Microreactor Technology in Medicinal Chemistry is a valuable practical reference for medicinal chemists, organic chemists, and natural products chemists, whether they are working in academia or in the pharmaceutical industry.
Local Note:
John Wiley and Sons
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