Title:
Protein folding and metal ions mechanisms, biology and disease
Author:
Gomes, Clùdio M., 1970-
ISBN:
9781439809655
Publication Information:
Boca Raton : CRC Press, 2011.
Physical Description:
xiv, 294 p. : ill., port.
Contents:
(Publisher-supplied data) ch. 1. Metal ions, protein folding, and conformational states : an introduction / Clùdio M. Gomes and Pernilla Wittung-Stafshede -- ch. 2. The folding mechanism of c-type cytochromes / Carlo Travaglini-Allocatelli, Stefano Gianni, and Maurizio Brunori -- ch. 3. The mechanism of cytochrome C folding : early events and kinetic intermediates / Eefei Chen, Robert A. Goldbeck, and David S. Kliger -- ch. 4. Stability and folding of copper-binding proteins / Irina Pozdnyakova and Pernilla Wittung-Stafshede -- ch. 5. Iron-sulfur clusters, protein folds, and ferredoxin stability / Sn̤ia S. Leal and Clùdio M. Gomes -- ch. 6. Folding and stability of myoglobins and hemoglobins / David S. Culbertson and John S. Olson -- ch. 7. Frataxin : an unusual metal-binding protein in search of a function / Annalisa Pastore -- ch. 8. Mechanism of human copper transporter Wilson's Disease protein / Amanda Barry, Zara Akram, and Svetlana Lutsenko -- ch. 9. A-Synuclein and metals / Aaron Santner and Vladimir N. Uversky -- ch. 10. Zinc and p53 misfolding / James S. Butler and Stewart N. Loh -- ch. 11. The octarepeat domain of the prion protein and its role in metal ion coordination and disease / Glenn L. Millhauser -- ch. 12. Metallopeptides as tools to understand metalloprotein folding and stability / Brian R. Gibney -- ch. 13. The folding landscapes of metalloproteins / Patrick Weinkam and Peter G. Wolynes.
Abstract:
"Interest in the uses and applications of metallo-chemistry in the life sciences continues to expand. This book provides a broad overview of metals and protein folding. It addresses fundamental aspects of the folding, stability, and design of metal binding proteins and peptides along with biological aspects related to the action of metallochaperones. The text features practical information related to methodologies, particular techniques, and bibliographic references. Readers will gain the molecular basis for protein-metal interactions and a good perspective on the applications of protein coordination chemistry in life sciences and biotechnology"--Provided by publisher.
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