Title:
Neuropeptides in neuroprotection and neuroregeneration
Author:
Nyberg, F.
ISBN:
9781439830635
Publication Information:
Boca Raton, Fla. : CRC Press, 2012.
Physical Description:
xi, 304 p. : ill.
Contents:
ch. 1. Neuropeptide systems : some basic concepts / Tomas Hk̲felt ... [et al.] -- ch. 2. Neuropeptide biosynthesis / Margery C. Beinfeld -- ch. 3. Neuropeptide degradation related to the expression of the physiological action of neuropeptides / Chikai Sakurada ... [et al.] -- ch. 4. Neuropeptides, isolation, identification, and quantitation / Jolanta Kotlinska and Jerzy Silberring -- ch. 5. Cellular and molecular processes of neuronal damage and mechanisms in neuroprotection and neuroregeneration : focus on brain ischemia / Gregor Z¿ndorf, Daniel Fr̲ster, and Georg Reiser -- ch. 6. Dynorphins in central nervous system pathology / Kurt F. Hauser ... [et al.] -- ch. 7. Postnatal stress procedures induce long-term endocrine and metabolic alterations involving different proopiomelanocortin- derived peptides / Alberto Loizzo ... [et al.] -- ch. 8. Prothymosin [alpha] : a novel endogenous neuroprotective polypeptide against ischemic damages / Hiroshi Ueda, Hayato Matsunaga, and Sebok K. Halder -- ch. 9. Influence of anabolic androgenic steroids on dynorphinergic pathways in rat's brain / Kristina Magnusson -- ch. 10. Angiotensin II receptors and neuroprotection / Robert E. Widdop ... [et al.] -- ch. 11. PACAP and cellular protection : cellular protection by members of the VIP/secretin family with an emphasis on pituitary adenylate cyclase-activating polypeptide (PACAP) / Lee E. Eiden -- ch. 12. General strategies of peptide synthesis / Aleksandra Misicka -- ch. 13. Addressing the interactions between opioid ligands and their receptors : classic and nonclassic cases / Luca Gentilucci -- ch. 14. Use of peptides as drug leads : a case study on the development of dipeptides corresponding to the heptapeptide substance P(1-7), with intriguing effects on neuropathic pain / Rebecca Fransson and Anja Sandstrm̲ -- ch. 15. Cognition-enhancing peptides and peptidomimetics / Fred J. Nyberg and Mathias Hallberg.
Abstract:
"Preface Over the past four decades, the number of peptides identified as neurotransmitters or neuromodulators in the central and peripheral nervous systems has significantly increased. These compounds, known as neuropeptides, have been recognized for playing an important role in the communication between cells in a variety of neuronal networks. Although, a considerable number of neuropeptides have been characterized so far, their quantity is limited compared to the number of precursor proteins that are actually found to be expressed in cells of the nervous system. Numerous studies have confirmed that neuropeptides are involved in a number of biological activities. These include modulation of brain reward, pain processing, and immune response, as well as neuroendocrine regulations, control of neurovegetative functions, and trophic effects. In recent years, it has become evident that the role of neuropeptides as fast-acting neurotransmitters is challenged by the observation that many of them may act as growth factors by stimulating cell proliferation and slow-acting mitogenesis. It has thus been demonstrated that a number of neuroactive peptides, such as pituitary adenylate cyclase-activating polypeptide (PACAP), adrenocorticotrophin (ACTH), opioid peptides, somatostatin, and substance P, may modulate proliferation and cell viability. Some peptides act as stimulatory factors on brain circuits involved in cognition, whereas others may act as inhibitory factors. Accordingly, many neuropeptide systems appear as important targets for neuroprotective drugs and drugs that promote neuroregeneration"--Provided by publisher.
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