This book constitutes the refereed post-conference proceedings of the 29th International Conference on Selected Areas in Cryptography, SAC 2022, held in Windsor, Canada, during August 24-26, 2022. The 21 full papers presented in this volume were carefully reviewed and selected from 53 submissions. The papers are categorized into the following topical sections: lattices and ECC; differential cryptanalysis; cryptographic primitives; isogeny-based cryptography I; block ciphers; differential cryptanalysis II; isogeny-based cryptography II; and protocols and PRFs.