chapter 1 Taking Aim at the Transmissible Spongiform Encephalopathies Infectious Agents -- chapter 2 Prions, the Protein Hypothesis, and Scientific Revolutions -- chapter 3 A Simulation Model for Evaluating the Potential for Spread of Bovine Spongiform -- chapter 4 Actions to Prevent Bovine Spongiform Encephalopathy from Entering the United States -- chapter 5 Overview of Transmissible Spongiform Encephalopathy in Cervids in the United States -- chapter 6 Bioassays for Prions -- chapter 7 Cyclic Amplification of Scrapie Prion Protein: Implications for Diagnosis -- chapter 8 The Enter Transmissible Spongiform Encephalopathies Assay: Chemiluminescent -- chapter 9 Sensitive Detection of Prion Proteins by Immunoassay: CEA/Bio-Rad Test -- chapter 10 The Diagnosis of Transmissible Spongiform Encephalopathies Using Differential Extraction and DELFIA -- chapter 11 In Vivo Diagnosis of Prion Diseases -- chapter 12 Diagnosis of Prion Diseases by Multispectral Techniques -- chapter 13 Detection of the Prion Protein in Blood Using a Fluorescence Immunoassay -- chapter 14 Prion Detection and Application to the Safety of Biological Products.