Cover image for Adaptive design methods in clinical trials
Title:
Adaptive design methods in clinical trials
Author:
Chow, Shein-Chung, 1955-
ISBN:
9781439839881
Edition:
2nd ed.
Publication Information:
Boca Raton : Taylor & Francis, 2012.
Physical Description:
xvi, 358 p. : ill.
Series:
Chapman & Hall/CRC biostatistics series
Series Title:
Chapman & Hall/CRC biostatistics series
Contents:
Protocol amendment -- Adaptive randomization -- Adaptive hypotheses -- Adaptive dose-escalation trials -- Adaptive group sequential design -- Statistical tests for adaptive seamless designs -- Adaptive sample size adjustment -- Two-stage adaptive design -- Adaptive treatment switching -- Bayesian approach -- Biomarker adaptive trials -- Target clinical trials -- Sample size and power estimation -- Clinical trial simulation -- Regulatory perspectives : a review of FDA draft guidance.
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